// 🇩🇰 / University of Copenhagen / Faculty of Health and Medical Sciences / Biotech Research & Innovation Centre / Supek group
// 🇪🇸 / BIST / Institute for Research in Biomedicine (IRB Barcelona) / Cancer Science programme / @GenomeDataLab
In the GenomeDataLab, we use statistical genomics and machine learning to study quality control that protects the integrity of information stored in the DNA and mRNA of the cell. We study how DNA repair and chromatin organization protect the human genome from mutations, and how QC mechanisms operate on the transcriptome to prevent expression of mutated mRNAs.
We perform large-scale bioinformatic studies of multi-omic data from human tumors (somatic mutations, and transcriptomes), human populations (germline variation) and metagenomes (incl. human microbiomes).
We study mechanisms for maintaining genome stability in human cells via statistical analyses of mutation patterns in cancer, which often result from deficient DNA repair [ 1 ]. Next, we are interested in how mRNA synthesis and turnover pathways shape genomes and transcriptomes in health and disease [ 2 ]. Finally, we combine experimental work and genomics to scan cancer genomes for drivers and genetic interactions to predict tumor evolution and identify novel synthetic lethalities [ 3 ]. More generally, we study novel approaches using artificial intelligence (AI) to infer DNA functionality from massive genomic data [ 4 ].
Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules.
I Toledano, F Supek*, B Lehner* (2024) Nature Genetics.
(w/ Ben Lehner lab, Sanger Institute/CRG)
Proton and alpha radiation-induced mutational profiles in human cells
TM Delhomme*, M Munteanu*, M Buonanno, V Grilj, J Biayna, F Supek (2023) Scientific Reports.
(w/ RARAF facility at Columbia university)
J Biayna, I Garcia-Cao, [...]
F Supek*, T Stracker* (2021)
PLOS Biology.
(w/ Travis Stracker lab, currently at NIH)
A Avgustinova*, A Symeonidi, [...],
F Supek*, S Aznar-Benitah* (2018)
Nature Cell Biology.
(w/ Aznar lab at IRB Barcelona)
+ other great ongoing collaborations 🤝
Ana Janic group at Universitat Pompeu Fabra, Barcelona, Spain.
Alexandra Avgustinova group at IRB Barcelona, Spain.
Irene Franco group at San Raffaelle Hospital, Milan, Italy.
Benedetta Bolognesi group at IBEC, Barcelona, Spain.
... interested in joint work? Drop us a note (Fran's contact here)
European Research Council ERC Consolidator Grant #101088342 STRUCTOMATIC "Mutational processes and impact of structural variants in somatic cells"
CaixaResearch foundation "POTENT-IMMUNO" -Boosting immunotherapy by genomic prediction and NMD inhibitors.
EU H-2020 "DECIDER" Clinical Decision via Integrating Multiple Data Levels to Overcome Chemotherapy Resistance in High-Grade Serous Ovarian Cancer
Novo Nordisk Foundation Starting Package Grant
We are further funded by the Horizon EU project "LUCIA" and the Danish Cancer Society. More information on projects >>>
PI is tenured (on leave) via the ICREA Research Professor program of the Catalan government.
Fran Supek is a member of the EMBO Young Investigator programme.
"Prediction is very difficult, especially about the future." -- Niels Bohr.
